PEG-IT! Reagents
                                  Advancing Drug Delivery & Product Development

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X - (CH2CH2O)n - Y

PEG-IT!™ Reagents

As shown in our catalog, PEG-IT!™ reagents are bifunctional. The functional groups on each terminus (X and Y) may be the same or different. If the functional groups are the same, the reagent is homobifunctional and will react with the same class of substituent on the target molecules. If the functional groups are different, the reagent is heterobifunctional and will react with different classes of substituents on the target molecules.

In addition, PEG-IT!™ reagents react to both "decorate" (conjugatively modify the surface of the molecule) and join two or more molecules together with covalent bonds (i.e., polymerize them). Although the extent of polymerization can be modulated by changes in reaction conditions, polymerized products are likely by-products of a PEGylation reaction, particularly with the longer (higher molecular weight) PEG reagents.

PEG-IT!™ reagents are available with polydisperse molecular weights or with a molecular weight that is more nearly monodisperse.

Key Benefits

bulletPEGylation is a widely used approach for improving the pharmaceutical and pharmacological properties of drugs and biologics or for anchoring ligands to biosensor elements.
bulletPEGylation of peptides and proteins typically results in:
bulletIncreased stability (with respect to temperature, pH, solvent, etc.).
bulletSignificantly reduced immunogenicity and antigenicity.
bulletResistance to proteases.
bulletMaintenance of catalytic activity, and improvements in solubility, among other features.
bulletIncreased liquid stability of the product and reduced agitation-induced aggregation.
bullet PEG-IT!™ reagents are available with a range of molecular weights and can be designed to have the end group chemistries that are most useful for your particular application.

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Last modified: 06/17/07. Copyright June, 2007